What are the mysterious factors that cause vitiligo?

Clinically, many patients miss the optimal time for diagnosis and treatment because they fail to seek medical attention promptly when vitiligo first appears. The causes of vitiligo are multifactorial, but the fundamental cause is the progressive decline or loss of the melanocytes' ability to produce melanin. This fundamental cause is mainly related to the following factors:

1. Melanocyte self-destruction factors

2. Endocrine factors

3. Psychological, neurological, and chemical factors

4. Autoimmune factors

5. Free radical damage factors

6. Oxidative stress factors

7. Relative deficiency of tyrosinase

8. Genetic factor

There is a common misconception that vitiligo is a skin disease that is easy to diagnose but difficult to treat. In fact, vitiligo is rarely noticed in its early stages, and many people fail to seek timely diagnosis and treatment, which leads to the expansion and worsening of the white patches.