Does Vitiligo Related to Endocrine System

In this article, I’m going to introduce you if vitiligo related to endocrine. The endocrine system composed of endocrine glands and endocrine cells, which forming an internal information delivery system on our body. The endocrine system also related to the neuron and immune system, both of system coordinate together to regulate the physiological activities of the body, and maintain internal environment’s stability. The hormone is a high efficacy activities substance secreted by the endocrine gland or endocrine cells. It exerts at internal fluid, blood.

Experiment study indicates melanin stimulating hormone, skin hormone and sex hormone can promote the synthesis and metabolism of melanin. While corticosteroids, epinephrine and nor-epinephrine, thyroxin and melatonin can restrain the synthesis and metabolism of the melanin. All these indicate vitiligo have a close relation with the endocrine system.

1. melanocyte stimulating hormone; the medical research show that melanocyte stimulating hormone may be secreted by thyrotropin secreting pituitary gland. The melancytes stimulating hormone consist of the a and beta two kind of the hormones. afa melancytes stimulating hormone have nothing difference for it, it has less effect or not effectiveness to the melancytes, There is a difference between for beta melanocyte estrogen, it also closely related to the pigment hyperplasia diseases.

2. Corticosteroid hormone is secreted by the adrenal cortex, Many patients develop original pigmented nevus and new pigment nevus. The local skin color become more deeper, all these is related to melanocyte stimulating hormone.

3. Epinephrine and nor-epinephrine animal experiment demonstrated. norepinephrine or norepinephrine can inhibit the effect of melanocyte stimulating hormone on melanocytes in vitro.

4. Sex hormones: including estrogen, progesterone can activate tyrosinase, and promote the synthesis of melanin melanocytes, so that the skin color become more deepened.

5. Melatonin:Skin depigmentation by binding with the specific receptors on melanocytes membranes.

6. Prostaglandin: prostaglandin E2 can stimulate the proliferation of melanocytes and promote melanin synthesis.