What Is the Isomorphic Response of Vitiligo?

The isomorphic response, which also called the Koebner phenomenon, it describes the skin lesions which appear at the site of injury. The isomorphic response of vitiligo is the new developed white spot or the white spot enlargement that usually happens after the scytitis or external injury. The isomorphic response is a common clinic phenomenon of vitiligo patients, and also it is a inducing factor of vitiligo.

The isomorphic response mostly happens on the developing stage of vitiligo. If it happens on the stable vitiligo, it could be a sign of spreading. The isomorphic response mostly happens on the injury area or skin soft-tissue infection area, normally after one month of lesions. However, the lesions of cuticle layer will not lead the isomorphic response in general.

The isomorphic response is relative to the melanocytes in the lesions basal cell layer. During the recovering of lesions, some cell factors, free radicals or the toxic substance produced by the bacteria make the abnormal melanocytes easier damaged. Indicated by the researches, the external medicines, varied scytitis, surgery trauma, rubbing and pressure on the skin they all could lead the aggravation of vitiligo, patients should pay more attention and avoid them.

The key point to prevent the isomorphic response is avoid the external injury, especially during the developing stage.